Type:MouseIgG
Applications:ICC;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;Rb
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-Supernatant
Immunogen:Fusionproteinaminoacids824-1203(cytoplasmicC-terminus)ofratmGluR5b(alsoknownasmetabotropicglutamatereceptor5,accessionnumberP31424).
Metabotropicglutamatereceptors(mGluRs)areG-proteincoupledreceptorsactivatedbyglutamate.Basedonsequencesimilarity,transductionmechanismsandagoNISTpotencies,mGluRsaresuBDividedintothreegroups:mGluR1/mGluR5,mGluR2/mGluR3,andmGluR4/mGluR6/mGluR7/mGluR8.mGluRsarewidelydistributedthroughoutthenervoussystemandareexpressedbybothneuronsandglialcells.mGluRshavebeensuggestedtoplayavarietyoffunctionalroles,amongwhichisinvolvementinsynapticplasticityunderlyinglearningandmemoryaswellaschronicpain.
Image:mGluR1/5stainingofadultrathippocampus.
mGluR1/5 isan importantpositivemodulatorsofsynapticfunctionandneuronalactivity.DysregulationofmGluR1/5signalingisimplicatedinsomedisordersofneurodevelopment,includingfragileXsyndrome(themostcommoninheritedformofintellectualdisABIlitiesandleADIngcauseofautism.Inadults,mGluR1/5relatedpathologiescouldcontributetodepression,epilepsyandpainsignaling.
Note:ThisantibodyhasbeendevelopedbyUCDavisunderagrantbyNIH.