
Type:RabbitIgG
Applications:WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:KLHcoupledsyntheticpeptide:KRTVWGAKQISATSLPTA(C)correspondingtoaminoacids487-504ofhuman

Caspasesareafamilyofcytosolicaspartate-specificcysteineproteasesinvolvedintheinitiationandexecutionofapoptosis.Theyareexpressedaslatentzymogensandareactivatedbyanautoproteolyticmechanismorbyprocessingbyotherproteases(frequentlyothercaspases).HumancaspasescanbesuBDividedintothreefunctionalgroups:cytokineactivation(caspase-1,-4,-5,and-13),apoptosisinitiation(caspase-2,-8,-9,-and-10),andapoptosisexecution(caspase-3,-6,and-7).
Caspasesareregulatedbyavarietyofstimili,includingAPAF1,CFLAR/FLIP,NOL3/ARC,andmembersoftheinhibitorofapoptosis(IAP)familysuchasBIRC1/NAIP,BIRC2/cIAP-1,BIRC3/cIAP-2,BIRC4/XIAP,BIRC5/Survivin,andBIRC7/Livin.IAPactivityismodulatedbyDIABLO/SMACorPRSS25/HTRA2/Omi.Cell-permeableandirreversIBLepeptideinhibitorsarealsoavailablefordifferentcaspases.
Image:Caspase10/bImmunoblottingofSDS-extractsfrom2x105humanJurkatcells.Extractswereelectrophoresedon20%gelsand dilutionwaswith1.0mg/mL
OtherReagentstoConsider:
Antibodies:
Caspase-2
Caspase-3
Caspase-3,active
Caspase-7
Caspase-9
Caspase-10b
Caspase-12
Bcl-2
ApoptosisAntibodies
CaspasesandCathepsins
CancerAntibodies
NeurodegenerativeDisease
Proteins
Bcl-2
AllApoptosisReagents
StemCellReagents