
Type:RabbitIgG
Applications:IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Reactswithresidues258-274(YRKSKRGPKQLAPHPNI)ofhumanPINK1.
![Picture[2]](images/neuromics/2017/A8x8ed0x66x1.jpg)
MutationsinthePTEN-inducedkinase(PINK1)genelocatedwithinthePARK6locusonchromosome1p35-p36haverecentlybeenidentifiedinpatientswithrecessiveearly-onsetParkinsondisease.DatasuggeststhatPINK1maybethesecondmostcommoncausativegenenexttoparkininparkinsonismwiththerecessivemodeofinheritance.
Image:InactivelesionsPINK1immunostainingwasintenseinreactiveastrocytes(arrows).DoublelabelingofPINK1(green)withtheastrocyticMarkerGFAP(red)demonstratedPINK1expressioninastrocytes(inset).
Note:JackVanHorssenetal.,usingthisPINK1,showedIHCstainingofastrocytesintemporalneocorticaltisueharvestedfromADandMDpatientspostmortem(inAD,PINK1wasfoundtocolocalizewithclassicsenileplaquesandvascularamyloiddepositions).seeFreeRADIcalBIOLOGyandMedicine.Volume50,Issue3,1February2011,Pages469-476.
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