
Type:RabbitIgG
Applications:IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:Wholeserum-lyophilized
Immunogen:Syntheticoxytocincoupledtobovinethyroglobulin(BTg)withcarbodiimide(CDI)linker.

Oxytocinisamammalianhormonethatactsprimarilyasaneuromodulatorinthebrain.ThereceptorisaG-protein-coupledreceptorwhichrequiresMg2+andcholesterol.Itbelongstotherhodopsin-type(classI)groupofG-protein-coupledreceptors.Oxytocinreceptorsareexpressedbyneuronsinmanypartsofthebrainandspinalcord,includingtheamygdala,ventromedialhypothalamus,septum,nucleusaccumbensandbrainstem.
Image:OxytocinstainingofRatHypothalamus(PVN/SON).Note:stainingiscompletelyeliminatedbypretreatmentof1mLofthedilutedantibodywith5μgofOxytocin.Pretreatmentof1mLofthedilutedantibodywithasmuchas100μgofvasopressindoesnotdiminishstaining.
Itisinvlolvedinregulatingmoodincludingperceptionsofstressandstressinduceddepression.Oxytocinmayplayaroleinautismandmaybeaneffectivetreatmentforrelated repetitiveandaffiliativebehaviors.Itisalsoknowtoproduceantinociceptionandanalgesiamakingitatargetforcertainpaintherapies.