
Type:MouseIgG
Applications:ICC;IHC;FC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:ProteinGPurified-liquid
Immunogen:HybridomaresultingfromthefusionofamousemyelomawithBcellsobtainedfromamouseimmunizedwithNS0cellstransfectedwithhumanSSTR2(hSSTR2;aa1-369;Accession#P30874).

SomatostatinReceptor2(SSTR2)isoneoffive7-transmembraneG-protein-coupledreceptorsforsomatostatins14and28.HumanSSTR2shares84%aaidentitywithmouseSSTR2withintheextracellulardomains.IsoformB(357aa)hasanalternateC-terminalcytoplasmicregionthatis12aashorterthanthatofisoformA(369aa,reportedas93kDa).Bothareexpressedinbrain,stomach,intestinalepithelia,pancreaticisletsandkidneytubules.IsoformBisalsoexpressedinparotid,thyroidandbronchialglands.
TheseSSTReceptorsfunctionintheregulationofnumerousphsiologicalprocessessuchasthesecretionofinsulin,glucagonandgrowthhormoneaswellascellgrowthinducedbyneuronalexcitationinboththecentralandperipheralnervoussystems.
Image:MDA-MB-231cellswerestainedwithanti-SSTR2(filledhistogram)orisotypecontrolantibody(openhistogram),followedbyAPC-conjugatedanti-mouseantibody.
OtherReagentstoConsider:
SomatostatinReceptor-2-SSTR2-Rabbit
SomatostatinReceptor-1-SSTR1
Autism/Asperger"sSyndromeAntibodies
Autism/Asperger"sSyndromeProteins
NeurodegenerativeDiseaseAntibodies
NeurodegenerativeDiseaseProteins
PainandInflammation
DiabetesandObesity