
Type:GoatIgG
Applications:IHC;WB;E
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:InsectcelllineSf21-derived,recombinanthumanActivinRIIA(rhActivinRIIA)extracellulardomain.

Activinsaredimericgrowthanddifferentiationfactorswhichbelongtothetransforminggrowthfactor-beta(TGF-beta)superfamilyofstructurallyrelatedsignalingproteins.ActivinshaveawiderangeofBIOLOGicalactivitiesincludingmesoderminduction,neuralcelldifferentiation,boneremodeling,hematopoiesis,andreproductivephysiology.Activinsarealsoinvolvedingrowthanddifferentiationofseveraltissuesfromdifferentspecies.
Image:stainingofActivinRIIAinhumanprostatecancer.CellswerestainedwithABC-HRP+AEC(red)andHaematoxylin(blue)counterstain.
TypeIIreceptorsareconsideredtobeconstitutivelyactivekinases.Activinhasbeensuggestedtobeanautocrine/paracrineregulatorinthehumanplacenta.ThepresenceofACVR2mRNAhasbeendemonstratedinhumantrophoblastcellsandthereisalsoevidenceofexpressionofthegeneinhumanbrainandovary.