
Type:RabbitIgG
Applications:IF;IHC;FC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:TASSSQPLLVHDDV

c-Kitistransmembranetyrosinekinaseencodedbythec-Kitprotooncogene.c-KitactstoregulateavarietyofBIOLOGical processesincludingcellproliferation,apoptosis,chemotaxisandadhesion.
Itplaysacriticalroleinactivationandgrowthinanumberofcelltypessuchashematopoieticstemcells,mastcells,melanocytesandgermcells.
Mutationsinc-Kithavebeenfoundtobeimportantfortumorgrowthandprogressioninavarietyofcancersincludingmastcelldiseases,gastrointestinalstromaltumor,acutemyeloidleukemia,Ewingsarcomaandlungcancer.Phosphorylationattyrosine721ofc-KitallowsbindingandactivationofPI3kinase.
Image:c-KITstainingofratskin(epidermis).c-KITdetectionwasdoneusinganti-rabbitCy3conjugatedantibodies(redcolor).DAPIwasusedtocounterstaincellnuclei(bluecolor).Workingdilution:1:100-1:300.
c-Kit:CustomerPublications