
Type:MouseIgG
Applications:E;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:ProteinGPurified-liquid
Immunogen:RecombinantmouseNeprilysin(aa52-750)extracellulardomain

Neprilysin(CD10),isazinc-dependentMetalloproteaseenzymethatdegradesanumberofsmallsmallsecretedpeptides,mostnotablytheamyloidpeptideimplicatedasacauseofAlzhemier’sDisease.
Itisexpressedonthecellsoflymphoblastic,Burkitt"s,andfolliculargerminalcenterlymphomas,immatureBcellswithinadultbonemarrowandoncellsfrompatientswithchronicmyelocyticleukemia(CML).CD10isalsopresentonbreastmyoepithelialcells,bilecanaliculi,fibroblasts,withespeciallyhighexpressiononthebrushborderofkidneyandgutepithelialcells.
Neprilysinisalsoassociatedwithotherbiochemicalprocesses,andisparticularlyhighlyexpressedinkidneyandlungtissues.Inhibitorshavebeendesignedwiththeaimofdevelopinganalgesicandantihypertensiveagentsthatactbypreventingneprilysin"sactivityagainstsignalingpeptidessuchasenkephalins,substanceP,endothelin,andatrialnatriureticfactor