
Type:RabbitIgG
Applications:IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:KLHconjugatedsyntheticpeptide-correspondingto13aminoacidsnearthecenterofhumanTLR6.

Toll-likereceptors(TLRs)areevolutionarilyconservedpattern-recognitionmoleculesresemblingthetollproteinsthatmediateantimicrobialresponsesinDrosophila.Theseproteinsrecognizedifferentmicrobialproductsduringinfectionandserveasanimportantlinkbetweentheinnateandadaptiveimmuneresponses.
Image:TLR6stainingof HumanThymus(formalin-fixed,paraffin-embedded)at5ug/mlfollowedbybiotinylatedgoatanti-rabbitIgGsecondaryantibody,alkalinephosphatase-streptavidinandchromogen.Protocolondata-sheet.
TLR6wasfirstidentifiedasaclosehomologofTLR1,sharing69%sequenceidentify.LikeTLR1,TLR6canformheterodimerswithTLR2,andtheseTLR6:TLR2dimerscoordinatemacrophageactivationbyGrampositivebacteriaandtheyeastcellwallparticlezymosan.Activationofthesecomplexesnotonlyinitiatesproinflammatorycascades,butalsocanleadtoapoptoticresponses.