
Type:RabbitIgG
Applications:IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:B;H;M;Pr
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:AsyntheticpeptidemadetoaC-terminalregionofthehumanCDR2protein.[Swiss-prot#Q01850].

Usinganti-Yoantibodies,threegeneshavebeencloned(CDR1-3).CDR2Cerebellardegenerationrelatedprotein2)suppressesthetranscriptionalactivityandDNAbindingofnuclearfactor-kappaBbyanunknownmechanism.TheneuronspecificexpressionofCDR2isregulatedbyapost-transcriptionalmechanism.
CDR2isanonconeuronalantigen;i.e.anantigenthatisexpressedbysystemictumorsandelicitsanimmuneresponsethatmaydevelopintoanautoimmuneneuronaldegeneration.Paraneoplasticcerebellardegeneration(PCD)isadisorderinwhichbreastorovariantumorsexpressCDR2,whichnormallyisexpressedincerebellarPurkinjeneurons
Image:CDR2 stainingof Purkinjeneurons inthe Human cerebellum
RelatedReagentstoConsider:
Antibodies:
AllImmuneResponseAntibodies
Cancer
NeurodegenerativeDisease
Proteins:
AllImmuneResponseProteins
Cancer
NeurodegenerativeDisease