
Type:MouseIgG
Applications:IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:HybridomaresultingfromthefusionofamousemyelomawithBcellsobtainedfromamouseimmunizedwithpurified,E.coli-derivedrecombinanthumanERK3(rhERK3;aa344-721;Accession#NP_002739).

Extracellularsignal-regulatedkinase3(ERK3)isaserine/threonineproteinkinasealsoknownasmitogen-activatedproteinkinase6(MAPK6)andp97MAPK.UnlikeERK1andERK2,ERK3lacksthephosphoacceptorsequenceT-E-Yinitsactivationloop.ThiskinasealsopossessesauniqueC-terminalextensionthatismissingintrADItionalMAPKs.Highlyunstable,ERK3israpidlydegradedfollowingN-terminalubiquitination.
ERK3isinvolvedinvariouscellularproliferation,differentiation,andcellcycleprogressioninresponsetoavarietyofextracellularsignalsmakingitusefulforthestudyofprocesseslikeangiogenesis,neurogenesisandtumOrigenesis.TheactivationofERKbyproinflammatorystimulimayplayimportantrolesininnateimmuneresponsesandautoimmunity.
Image:Extracellularsignal-regulatedkinase3(ERK3) stainingof paraffin-embeddedhumanbreastcancertissuesectionsusing8µg/mLmouseanti-humanERK3monoclonalantibody. Tissueswerestainedusinganti-mouseHRP-DAB(brown)andcounterstainedwithhaematoxylin(blue).