
Type:RabbitIgG
Applications:ICC;IF;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
Laminins arehigh-molecularweight (~400kDa)proteinsofthe extracellularmatrix. TheyareanimportantandBIOLOGicallyactivepartofthebasallamina,whichis oneofthelayersofthe basementmembrane,aproteinnetworkfoundationformostcellsandorgans,influencingcelldifferentiation,migration,andadhesion. Lamininsareheterotrimericproteinsthatcontainanα-chain,aβ-chain,andaγ-chain.Thedistributionofthedifferentlamininisoformsistissue-specific.Thelamininmoleculesarenamedaccordingtotheirchaincomposition.
Laminin-111isoneof thefirst laminin isoformstobe discovered. The“111”identifiestheisoform’schaincompositionofα1β1γ1.Laminin-111ispredominantlyexpressedintheembryonicepithelium,butcanalsobefoundinsomeadultepitheliumsuchasthe kidney,liver, testis, ovaries,andbrain bloodvessels. Laminin-111hasbeenidentifiedasacrucialmoleculefordevelopmentoftheembryo,geneticablationoflaminin-111resultsinembryonicdeath.