
Type:ChickenIgY
Applications:IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:Ca;H;M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:Wholeserum-liquid
Immunogen:Ratperipherinwasexpressedinbacteriaandpurifiedfrominclusionbodies.

PeripherinisatypeIIIintermediatefilamentfoundinitiallyinsensoryneuronsoftheperipheralnervoussystem(PNS). ItservesasaMarkerforautonomicandsensoryneuronsinthePNSandmotorneuronsintheCNS.Peripherinisadiagnosticmarkerinamyotrophiclateralsclerosisandcertainneuronally-derivedtumors.Braininjuriescanalsotriggerexpressionofperipherinandtheformationofperipherinaccumulationsinneuronsthatarenormallysilentforthisgene.
Peripherinisalsoexpressedincertainneuroendocrinetumorsandintheinsulinproducingcellsofthepancreas. Autoantibodiestoperipherinarealsofrequentlyseenintheseraofpatientswithdiabetes.
Image:Ratmixedneuron/glialculturesstainedwithPeripherin(greenchannel)andNeurofilamentalpha-internexin/NF66 (greenchannel).Theseculturescontainmostlyneuronswhicharerichinalpha-internexin,andasubgroupwhichhavealargeamountofperipherinalso,suchastheprominentcellinthemiddleofthemicrograph.Sincethiscellexpresseslargeamountsofperipherinandalpha-internexin,thegreenandredsignalssuperimposetoproduceagoldencell.BlueisaDNAstain.Protocolondata-sheet.