
Type:RabbitIgG
Applications:WB;IP
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;Pr;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Peptidecorrespondingtoresiduesaroundvaline293ofhumanpresenilin1

Alzheimer"sdisease(AD)patientswithaninheritedformofthediseasecarrymutationsinthepresenilinproteins(PSEN1;PSEN2).Presenilinsformthecatalyticsubunitofthegamma-secretasecomplex,anendoproteasecomplexthatcatalyzestheintramembranecleavageofintegralmembraneproteinssuchasNotchreceptorsandAPP(beta-amyloidprecursorprotein).EvidencesuggestscleavageofAPPbygamma-secretaseandtheproductionofAbeta(42aa)islikelytoplayaimportantorcasualroleinthedevelopmentofAlzheimer"sdisease
Image:Presenilin1Antibodydetectsendogenouslevelsofthecarboxy-terminalfragmentofpresenilin1(~22kDa).Theantibodydetectsthefulllengthprotein(55kDa)toalesserextent.WesternblotimageshowsextractsfromHeLa(1),SK-N-MC(2)andCOS(3)cellsprobedwithPresenilin1antibody.
Note:Westernblotandimmunoprecipationprotocolsondatasheet