Secretagogin is a member of the EF-hand (E-helix-loop-F-helix-hand) superfamily of calcium-binding proteins. Secretagogin is highly expressed in the pancreatic islets of Langerhans and neuroendocrine cells. It is also expressed in numerous brain regions. he expression pattern of secretagogin is not conserved from rodents to humans. While human brain reveals an expression maximum in the cerebellum, in rat and mouse brain by far the highest expression of secretagogin is found in the olfactory bulb. Secretagogin has been shown to be involved in insulin secretion from pancreatic beta cells and is a strong candidate as a biomarker for endocrine tumors, and might be a useful biomarker for neuronal damage, stroke, and eventually psychiatric conditions. Moreover, secretagogin has been hypothesized to exert a neuroprotective role in neurodegenerative diseases like Alzheimer’s disease.

Image: Image: Adult mouse olfactory bulb floating section stained with RA22122, our rabbit polyclonal antibody to secretagogin in red (1:1,000 dilution) and chicken polyclonal antibody to calretinin: CH22116  (1: 1,000) in green. Secretagogin is predominantly expressed in cells in external plexiform lay (EPL) and granular cell lay (GCL) in olfactory bulb. Secretagogin coexists with calretinin in some cells in GCL, so these cells appear yellow.  Secretagogin is found in both cell body and processes. Blue is a DNA stain.

This antibody was raised against human secrtagogin protein expressed in and purified from E.coli.