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Neuromics/CCK-8 (Cholecystokinin Octapeptide)/RA20078/100 ul

Type:RabbitIgG
Applications:IF;IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:Wholeserum-liquid
Immunogen:SulfatedCCK-8(26-33)coupledtobovinethyroglobulin(BTg)withglutaraldehyde.

Cholecystokinin(CCK)isoneofthemostimportanthormoneregulatorsofthedigestiveprocess.Thepeptideisconcentratedintheproximalsmallintestine(CCKcells)andissecretedintothebloodinresponsetotheingestionofproteinsandfats,whereitsactionsincludethestimulationofpancreaticsecretion,themodulationofinsulinoutput,theregulationofgastricemptying,andgallbladdercontraction.InthecentralnervoussystemCCKergicfibresarewidespread,beingparticularlyabundantinthecerebralcortex.Insomemesolimbicneuronsprojectingtothenucleusaccumbens,CCKiscolocalisedwithdopamineandithasbeensuggestedthatCCKmightfacilitatethefunctionofdopamineineventssuchasstimulusrewardassociativebehaviour.SecretionofCCKfromthemurinetumourcelllineSTC1hasbeenshowntobestimulatedbypituitaryadenylatecyclaseactivatingprotein(PACAP)andhasraisedthepossibilitythatPACAPmayfunctionasaneuromodulatorofCCKreleasefromgutendocrinecellsinvivo.CCK-8isalsosUSPectedtoheightenpainsensationindiabetics.
Image:Cholecystokinin8terminalsandfibersinratdorsalhorn(spinalcord),vibratomesections,ABCdetection.