
Type:GoatIgG
Applications:IHC;WB;E
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:RecombinantmouseLeptinR

Leptinisaproductofthemouseobesegene.Micewithmutationsintheobesegenethatblockthesynthesisofleptinareobeseanddiabeticandhavereducedactivity,metabolism,andbodytemperature.Ratleptinsharesapproximately96%and82%sequenceidentitywiththemouseandhumanprotein,respectively.TheexpressionofleptinmRNAisrestrictedtoADIposetissue.
Leptinreceptor(OBR),alsonamedB219,isatypeIcytokinereceptorfamilyproteinwithsignificantaminoacidsequenceidentitywithgp130,G-CSFreceptor,andtheLIFreceptor.MultipleisoformsofhumanandmouseOBR,includingalongform(OBRL)withalargecytoplasmicdomaincapableofsignal-transduction,andseveralreceptorisoformswithshortcytoplasmicdomains(OBRS)lackingsignaltransducingcapABIlities,havebeenidentified.
Image:LeptinReceptorStaining of Cryostattissuesectionsofratbrain withHRP-DAB (brown)andHaematoxylin(blue).
OtherReagentstoConsider:
Leptin-Goat
LeptinMouseMonoclonal
LeptinReceptorforFlowCytometry
DiabetesandObesityAntibodies
LepRb/OBRb
AllDiabetesandObesityAntibodies
AllDiabetesandObesityProteins