
Type:GoatIgG
Applications:WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:ProteinGPurified-liquid
Immunogen:WholeRSVvirions(subgroupA-Longstrain)wereusedasanimmunogen.DetectsG,F,NandM2proteinsofRSV.

Malondialdehyde(MDA)isanaturalproductformedinallmammaliancellseitherasaproductoflipidperoxidation,orasaby-productofprostaglandinandthromboxanebiosynthesis.AlthoughMDAcanbebrokendownbyaldehydedehydrogenases,itsproductionisacceleratedbyoxidativestressandwhenitsconcentrationsreachcriticallevels,itmayescapethisdetoxificationprocess.Itishighlyreactiveandknowntobindcovalentlywithprimaryaminogroupsofproteins,phospholipids,orDNA,buthasnoknownphysiologicalfunction.Thiscovalencemodificationofcellularmoleculesmaycausestructuralmodifications,whichresultsindysfunctionorinactivation.MDAistoxicandhasbeenimplicatedinaging,mutagenesis,carcinogenesis,rADIationdamageandanumberofotherpathologicalprocesses.
MDAisknowntoincreaseintissueandplasmasampleswithage.ItisknowntobindtolowdensitylipoproteinresultingintherecognitionoftheMDA-modifiedLDLbyscavengerreceptorsonmacrophages.Ithasalsobeenshowntobepresentinrenalglomerularlesionsindiabetics,implicatingoxidativestressasbeinginvolvedinthepathogenesisofdiabeticnephopathy.MDAhasbeenshowntobeincreasedinthebrainsofagedindividualsandfurtherincreasedinAlzheimerbrains.
Image:WesternblotofagedcontrolandAlzheimer"sbrainhomogenatesusinga1:3,000dilutionofmalondialdehydeantibody.