
Type:MouseIgG
Applications:IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:ProteinGPurified-liquid
Immunogen:HybridomaresultingfromthefusionofamousemyelomawithBcellsobtainedfromamouseimmunizedwithKLH-conjugatedhumanOrexinBpeptide(hOrexinB).
OrexinAandorexinBareneuropeptidehormonesderivedfromproteolyticprocessingofthesameorexinprecursorprotein.Orexinsarenamedfortheirorexigenic-inducing(orexis;Greekforappetite)activity.Theyarereleasedfromthehypothalamusandareinvolvedintheregulationofsleepingpatterns,feeding,andmetabolism.OrexinsAandBarelessthan50%aminoacididentical.OrexinAisaligandfortwo7-transmembraneorexinreceptors,OX1RandOX2R,whileorexinBpreferentiallybindsOX2R.Defectsintheorexinprecursorareacauseofnarcolepsyinhumans.
Image: OrexinB andp38alpha weredetectedinfrozensectionsofmousebrainstemusingmouseanti-humanOrexinBmonoclonalantibody(red)andrabbitanti-human/mouse/ratp38alphaaffinity-purifiedpolyclonalantibody(green).
ThisantibodywasselectedspecificallyforitsABIlitytorecognizehumanOrexinBinimmunohistochemistryapplications.Itdoesnotcross-reactwithhumanOrexinA.