
Type:RabbitIgG
Applications:IHC;WB;IP
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:Wholeserum-lyophilized
Immunogen:C-terminalfusionproteinrepresentingaminoacids1253-1391ofratNMDAR2A.

N-methyl-D-aspartatereceptor(NMDAR)formsaheterodimerofatleastoneNR1andoneNR2A-Dsubunit.MultiplereceptorisoformswithdistinctbraindistributionsandfunctionalpropertiesarisebyselectivesplicingoftheNR1transcriptsanddifferentialexpressionoftheNR2subunits.NR1subunitsbindtheco-agoNISTglycineandNR2subunitsbindtheneurotransmitterglutamate.
NMDAreceptorsareamongthemoststudiedreceptorsinneurosciencebecausetheyareinvolvedinneuronalcelldevelopmentandplasticity,acellularcorrelateforlearning.NMDAreceptorsarealsoimplicatedinseveraldisordersofthecentralnervoussystemincludingepilepsyandischemicneuronalcelldeath.NMDAreceptorsalsoappeartobeatargetforethanolatphysiologicalconcentrationsandthereforemayplayasignificantroleinalcoholism.
Image:NMDAR2AWesternBlotAnalysis:
Lane1:RatHippocampus
Lane2:HEKcellstransfectedwithNMDANR2A
Lane3:HEKcellstransfectedwithNMDANR2B
Lane4:HEKcellstransfectedwithNMDANR2C
Lane5:sameasLane2butantibodypreabsorbedwithNMDANR2A