
Type:MouseIgG
Applications:ICC;IF;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;P;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Proteinsequence1-42,epitopeissequence1-16

Amyloidbeta-protein(Abeta)isassociatedwithneuronalinjuryanddeathinAlzheimer"sdisease.Theseproteinsarethemaincomponentsofamyloidplaques.Abeta42playsabiggerroleinneurogenerationandismorestronglyassociatedwithAlzheimer"sdiseasethanAbeta40.
Image:Immunohistochemicalanalysisofparaffin-embeddedAlzheimer’shippocampususingThioflavinS(leftpanel)andMO22141usingtheHRP-DABstainingtechnique.LeftimageshowsasectionstainedwithThioflavinS,afluorescentreagentwhichbindstobothsenileplaques(SP)andneurofibrillarytangles(NFT),thetwohallmarklesionsofAlzheimer’sdisease.Lipofuscingranules(LP)areseeninnormalagingbrain,butareautofluorescentandsocanalsobeseeninthisimage.MO22141showstrongstainingonlyofthesenileplaques.TherightimageshowMO22141stainingofanadjacentsection,showingstrongstainingofthesenileplaques,withmoreminorstainingofbloodvessels.