
Type:MouseIgG
Applications:IF;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid

DJ-1,alsoknownasPark7,isacytoplasmicproteinthatbelongstotheThiJ/Pfp1/DJ1superfamilythatfunctionsasproteinchaperones,catalases,proteasesandkinases.DJ-1wasoriginallyclonedasanoncogenethatcooperativelytransformscellstogetherwithH-ras.MutationsintheDJ-1geneareassociatedwithrareformsofautosomalrecessiveearly-onsetParkinson"sdisease.DJ-1mayalsofunctionasaredox-sensitivechaperone,asasensorforoxidativestress,anditapparentlyprotectsneuronsagainstoxidativestressandcelldeath.AugmentingDJ-1activitymightprovidenovelapproachestotreatingchronicneurodegenerativeillnessessuchasParkinson"sdiseaseandacutedamagesuchasstroke
Image:HeLacellsstainedwithMO22148(green),andCH22108chickenantibodytovimentin(red)andDNA(blue).MO22148antibodyrevealsstrongcytoplasmicstainingforDJ-1inhumancells,butdoesnotbindtorodentcells