
Type:RabbitIgG
Applications:IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Syntheticpeptidecomprisingresidues513-526[TERHGLKEPKRVEE]ofthehumanNurr1protein.ReactswithratandmouseNurr1.

AlternateNames:NOT;NURR1;TINUR;NuclearReceptorofTCells;NuclearReceptorRelated1;TranscriptionallyInducIBLeNuclearReceptor;NuclearReceptorSubfamily4,groupA,member2;nuclearreceptorsubfamily4,groupA,member2.
TheNurr1gene encodes a member of the steroid-thyroidhormone-retinoidreceptorsuperfamily.Theencodedproteinmayactasatranscriptionfactor.Mutationsinthisgenehavebeenassociatedwithdisorders related to dopaminergicdysfunction, includingParkinson"s.
Nurr1isastemcellMarkerandcooperateswithPITX3topromoteterminalmaturationofmurineandhumanembryonicstemcellculturestoamidbraindopamineneuronphenotype. Inaddition,Nurr1isinvolvedintheregulationofcorticotropin-releasinghormone(CRH),whichmaybelinkedtoandassociatedwithrheumatoidarthritis.
Image:Nurr1stainingofratadulthippocampus.Tissuewasfixedinparaformaldehydeandcutin20micronsections.Dulution1:100.