
Type:RabbitIgG
Applications:IF;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:Frozen-liquid
Immunogen:PurifiedrecombinantproteinstructurefromE.coli.correspondingtotheshortestversionofthe8humantauproteins,sotheantibodyisexpectedtobindtoall8isoforms.

TauisarelativelylowmolecularweightmemberofthemicrotubuleassociatedproteinorMAP.Therecombinantproteinusedtomakethisantibodyistheshortestversionofthe8humantauproteins,sotheantibodyisexpectedtobindtoall8isoforms.
Image:E18PrimaryRat HippocampalNeurons fixedandimmunostainedwith Tua/MAPT+. ThecellswerealsostainedingreenwithourmonoclonalantibodytoUbiquitinC-terminalHydrolase1(UCHL1). SincetheperikaryacontainbothUCHL1andTau,theredandgreensignalssuperimpose,givingayellowcolor,whiletheprocesses,whichcontainrelativelymuchmoretau,appearred.BluestainisDAPIandrevealscellnucleiofsomenonneuronalcellsinthesecultures.ProtocolonData-sheet.
TauisamajorcomponentoftheneurofibrillarytanglesofAlzheimer"sdisease.Inaddition,numerousdifferentpointmutationsinthetaugenearecausativeofFronto-temporaldementiawithParkinsonismlinkedtochromosome17