
Type:RabbitIgG
Applications:ICC;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:Wholeserum-lyophilized
Immunogen:Syntheticpeptide(Rat)fromtheN-terminalextracellulardomainconjugatedtoimmunogeniccarrierprotein.

NeurotensinReceptor3,also knownasSortilin, isamemberofthefamilyofVps10p-domainreceptors,andisfoundexpressedinbrain,spinalcordandmuscle. NTS3 isexpressedduringembryogenesisinareaswherenervegrowthfactor(NGF)anditsprecursor,proNGF,havewell-characterizedeffects.
Image:NTS3stainingofratbrain(cortex)-Dilution-1:1000
ItisrequiredforproteintransportfromtheGolgiapparatustothelysosomesbyapathwaythatisindependentofthemannose-6-phosphatereceptor(M6PR).AlsorequiredforproteintransportfromtheGolgiapparatustotheendosomes.PromotesneuronalapoptosisbymediatingendocytosisoftheproapoptoticprecursorformsofBDNF(proBDNF)andNGFB(proNGFB).Alsoactsasareceptorforneurotensin.MaypromotemineralizationoftheextracellularmatrixduringosteogenicdifferentiationbyscavengingextracellularLPL.ProbablyrequiredinADIpocytesfortheformationofspecializedstoragevesiclescontainingtheglucosetransporterSLC2A4/GLUT4(GLUT4storagevesicles,orGSVs).ThesevesiclesprovideastablepoolofSLC2A4andconferincreasedresponsivenesstoinsulin.MayalsomediatetransportfromtheendoplasmicreticulumtotheGolgi.