
Type:RabbitIgG
Applications:IF;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Phosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser503oftheKv3.1-SubunitVoltageGatedPotassiumChannel,conjugatedtokeyholelimpethemocyanin(KLH).

Voltage-gatedK+channelsareimportantdeterminantsofneuronalmembraneexcitABIlity.Moreover,differencesinK+channelexpressionpatternsanddensitiescontributetothevariationsinactionpotentialwaveformsandrepetitivefiringpatternsevidentindifferentneuronalcelltypes(Maletic-Savaticetal.,1995;Pongs,1999;BlaineandRibera,1998;BurgerandRibera,1996).TheKv3.1potassiumchannelisexpressedathighlevelsinneuronsthatcharacteristicallyfirerapidtrainsofactionpotentials(Ganetal.,1999).
Image:CHOcellsexpressingrecombinantVoltageGatedPotassiumChannelKv3.1.Theimagesshowimmunohistochemicalstainingofmedialnucleusofthetrapezoidbody(MNTB)cellswiththeantibodyspecificforphosphoSer503inKv3.1,thevoltagegatedpotassiumchannel.Theimageintheleftpanelshowscontrolcells.TheimageattherightshowscellsthathadbeenexposedtotheproteinkinaseCactivatorPMA.
Particularlyhighlevelsofthischannelarefoundinneuronsoftheauditorybrainstem.Theseneuronsappeartoparticipateinneuralcircuitsthatdeterminetheintensityandtimingofauditorystimuliandusethisinformationtodeterminethelocationofsoundsinspace(vonHehnetal.,2004).