
Type:GoatIgG
Applications:IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:PeptidewithsequenceTTLAGAVPRMM-C,fromtheNTerminusoftheproteinsequenceaccordingtoNP_000429.2;NP_039230.1;NP_852122.1;.1NP_852123.1;NP_852124.1;NP_852125.1;NP_852126.1.

PAX3isamemberofthepairedbox(PAX)familyoftranscriptionfactors. Itisacriticalfactorfortheproperformationofthemammaliannervous,cardiovascular,andmuscularsystems.
MutationsinPax3resultingincompletelossoffunctionhaveprovidedimportantmodelsforthestudyofneuraltubedefects,congenitalcardiacdiseasesaffectingtheoutflowtractoftheheart,andfortheelucidationofthegeneticpathwaysregulatingmyogenesis.Inhumans,haploinsufficiencyofPAX3resultsindeafness,pigmentationdefects,andotherneuralcrest-relatedabnormalitiesaswellasvariable-limbmyopathy.
Image:PAX3(dilution:3.0µg/ml)stainingofparaffinembeddedHumanEsophagus.SteamedantigenretrievalwithcitratebufferpH6,AP-staining.
Note:Thisantibodyisexpectedtorecogniseall7reportedhumanisoforms(asrepresentedbyNP_000429.2;NP_039230.1;NP_852122.1;.1NP_852123.1;NP_852124.1;NP_852125.1andNP_852126.1).