
Type:MouseIgG
Applications:ICC;IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:ProteinGPurified-liquid
Immunogen:E.coli-derived,recombinantratSRY(sexdeterminingregionY)box10(rrSOX10).Clone:20B7
SOX10isamemberoftheSRY-relatedHMG-boxfamilyoftranscriptionfactors.Itisrequiredfortheterminaldifferentiationofoligodendrocytesandmyelination.Intheperipheralnervoussystem,SOX10maintainspluripotencyofneuralcreststemcellsandsuppressesneuronaldifferentiation.
Theencodedproteinmayactasatranscriptionalactivatorafterformingaproteincomplexwithotherproteins.Thisproteinactsasanucleocytoplasmicshuttleproteinandisimportantforneuralcrestandperipheralnervoussystemdevelopment.MutationsinthisgeneareassociatedwithWaardenburg-ShahandWaardenburg-Hirschsprungdisease.
Note:ThisantibodywasselectedforitsABIlitytodetectratSOX10inimmunohistochemistryexperiments.Epitope-mappingexperimentsindicatedthatclone20B7recognizesadeterminantinthefirst65aminoacids,whichcontainssequencesuniquetoSOX101.
Reference:
1.Lo,L.etal.,2002,Development129:1553-1567.