
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllPEDFisanoninhibitoryserpinwithneurotrophic,anti-angiogenic,andanti-tumOrigenicproperties.PEDFisa50,000daltonglycoproteincreatedandsecretedinmanytissuesallthewaythroughthebody.Akeycomponentoftheanti-angiogenicactionofPEDFistheinductionofapoptosisinproliferatingendothelialcells.Additionally,PEDFiscapabletoinhibittheactivityofangiogenicfactorssuchasVEGFandFGF-2.Theneuro-protectiveeffectsofPEDFareachievedthroughsuppressionofneuronalapoptosisinducedbyperoxide,glutamate,orotherneurotoxins.Therecognitionofalipase-linkedcellmembranereceptorforPEDF(PEDF-R)thatbindstoPEDFwithhighaffinityshouldfacilitatefurtherelucidationoftheunderlyingmechanismsofthispluripotentserpin.Todate,PEDF-Ristheonlysignalingreceptorknowntobeusedbyaserpinfamilymember.TheuniquerangeofPEDFactivitiesassociateitasapotentialtherapeuticagentforthetreatmentofvasculaturerelatedneurodegenerativediseasessuchasage-relatedmaculardegeneration(AMD)andproliferativediabeticretinopathy(PDR).PEDFinadditionhasthepotentialtobefunctionalinthetreatmentofvariousangiogenesis-relateddiseasesincludinganumberofcancers.