
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllPTEN,atumorsuppressor,hasbeenimplicatedinalargenumberofhumantumorsandisconservedfromhumanstoworms.CharacterizationofPTENproteinshowedthatitisaphosphatasethatactsonproteinsandon3-phosphorylatedphosphoinositides,andcanthereforemodulatesignaltransductionpathwaysthatinvolvelipidsecondmessengers.Recentresultsindicatethatatleastpartofitsroleistoregulatetheactivityoftheserine/threoninekinaseAKT/PKB,andthusinfluencecellsurvivalsignaling.
References:
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