Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
BrainDerivedGrowthFactor(BDNF) promotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.Majorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsofthecns.theversatilityof BDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(ltp),long-termdepression(ltd),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.NewTestimonial:"IamreplyingonbehalfonJoanHan,whoyousentanemailtoregardingourpurchaseof BDNFandBDNF,CF.WehavesuccessfullyutilizedyourBDNFinourexperiments.Thankyouforcheckingin."Chiew-JenOng,NIH
Image: BDNFproteinstructureandsequence.
References:
1.[Brain-derivedneurotrophicfactorandpsychiatricdiseases] TanpakushitsuKakusanKoso2007Jul;52(8):900-5
2.Anterogradetransportandsecretionofbrain-derivedneurotrophicfactoralongsensoryaxonspromoteSchwanncellmyelination. JNeurosci2007Jul11;27(28):7597-603
3.Repeatedco-treatmentwithimipramineandamantADIneinduceshippocampalbrain-derivedneurotrophicfactorgeneexpressioninrats. JPhysiolPharmacol2007Jun;58(2):219-34
4.Brain-derivedneurotrophicfactorandTrkBmodulatevisualexperience-dependentrefinementofneuronalpathwaysinretina. JNeurosci2007Jul4;27(27):7256-67
5.AlocalreductionincorticalGABAergicsynapsesafteralossofendogenousbrain-derivedneurotrophicfactor,asrevealedbysingle-cellgeneknock-outmethod. JNeurosci2007Jul4;27(27):7234-44
6.Brain-derivedneurotrophicfactorregulatescholesterolmetabolismforsynapsedevelopment. JNeurosci2007Jun13;27(24):6417-27
