
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
HepatocyteGrowthFactor(HGF)isamultifunctionalgrowthfactorwhichregulatesbothcellgrowthandcellmotility.Itexertsastrongmitogeniceffectonhepatocytesandprimaryepithelialcells.HGFsynergizeswithInterleukin-3andGM-CSFtostimulatecolonyformationofhematopoieticProgenitorcellsinvitroandmay,therefore,alsomodulatehematopoiesis.
Image:HGFStructureandSequence.
References:
1.Combinedstrategyusingmyoblastsandhepatocytegrowthfactorindilatedcardiomyopathichamsters. AnnThoracSurg2007Jul;84(1):134-41.
2.Hepatocytegrowthfactorandvisfatininelderlybedriddenpatients. JAmGeriatrSoc2007Jun;55(6):963-5.
3.InducingeffectsofhepatocytegrowthfactorontheexpressionofvascularendothelialgrowthfactorinhumancolorectalcarcinomacellsthroughMEKandPI3Ksignalingpathways. ChinMedJ(Engl)2007May5;120(9):743-8.
4.EnhancedhepatocytegrowthfactorsignalingbytypeIItransforminggrowthfactor-betareceptorknockoutfibroblastspromotesmammarytumOrigenesis. CancerRes2007May15;67(10):4869-77.
5.Effectsofadenoviral-mediatedhepatocytegrowthfactoronliverregenerationaftermassivehepatectomyinrats. ActaMedOkayama2007Apr;61(2):81-8.
6.Theroleofhepatocytegrowthfactorinthedifferentiationofdendriticcellsfromperipheralbloodmonocytes. SaudiMedJ2007May;28(5):688-95.