Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllBMP-2belongstotheBone-growthregulatoryfactorsthataremembersofthetransforminggrowthfactor-beta(TGF-beta)superfamilyofproteins.Theyaresynthesizedaslargeprecursormoleculeswhicharecleavedbyproteolyticenzymes.Theactiveformcanconsistofadimeroftwoidenticalproteinsoraheterodimeroftworelatedbonemorphogeneticproteins.
Images:At45days,thebonemineralizationratesofthe(A)rhBMP-2/CPCandthe(B)rhBMP-2/GM/CPCgroupsweregreaterthanthoseofthe(C)untreatedgroup,andtheratesoftherhBMP-2/GM/CPCgroupweregreaterthanthoseoftherhBMP-2/CPCgroup.However,therewerenodifferencesinthemineralizationratesamongthe(D)rhBMP-2/CPC,(E)rhBMP-2/GM/CPC,and(F)untreatedgroupsat140days(Doublefluorescentlabeling;originalmagnification,×100).ClinicalOrthopaedicsandRelatedResearch®©TheAssociationofBoneandJointSurgeons®201010.1007/s11999-010-1321-9
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