
Type:Protein
SpeciesReactivity:H;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllContactin1(CNTN1)isamemberofthecontactinsubgroupwithintheimmunoglobulinsuperfamily.Itwasoriginallydesignatedcontactininhuman,F3inrodents,andF11inchicken.OthermembersofthisfamilyinhumanincludeContactin2(TAG1),Contactin5(NB2),andContactin6(NB3).Additionalfamilymembershavebeendescribedinotherspecies.CNTN1shareslessthan50%aminoacidsequenceidentitywiththeothercontactins.ThehumanandrodentCNTN1proteinsshare96%sequenceidentity.The998aminoacidmatureproteincontains6Iglikedomainsand4fibronectintypeIIIlikedomains,andisattachedtothemembranebyaGPIanchor.CNTN1isdifferentiallyexpressedinnumerousneuronaltissuesandfunctionsinnervoussystemdevelopment.Itassociateswithtwoothercellsurfaceproteinsbelievedtoparticipateinsignaltransduction,receptorproteintyrosinephosphatasebeta(RPTPβ)andContactinassociatedprotein(Caspr).ReportedligandsincludeNrCAMandtheextracellularmatrixglycoprotein,tenascin.