
Type:Protein
SpeciesReactivity:H;M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
GDNFpromotesthesurvivalanddifferentiationofdopaminergicneuronsinculture,andisabletopreventapoptosisofmotorneuronsinducedbyaxotomy.Theencodedproteinisprocessedtoamaturesecretedformthatexistsasahomodimer.ThematureformoftheproteinisaligandfortheproductoftheRET(rearrangedduringtransfection)protooncogene.InadditiontothetranscriptencodingGDNF,twoadditionalalternativetranscriptsencodingdistinctproteins,referredtoasastrocyte-derivedtrophicfactors,havealsobeendescribed.MutationsinthisgenemaybeassociatedwithHirschsprungdisease.GDNFenhancessurvivalandmorphologicaldifferentiationofdopaminergicneuronsandincreasestheirhigh-affinitydopamineuptake.
Image: ImmunofluorescenceforhN2HumanNeuronsDiscoveryKitdifferentiatedinthepresenceof25ng/mlGDNF.Cellswerealsocounterstainedfornuclei(DAPI)and Tuj1-Neuron-specificclassIIIbeta-tubulinandTH-TyrosineHydroxylase.
hGDNFRecombinantProtein:CustomerPublications