
Type:Protein
SpeciesReactivity:R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllMAG(MyelinAssociatedGlycoprotein),atypeItransmembraneglycoproteincontainingfiveIglikedomainsinitsextracellulardomainisanadhesionmoleculebelongingtotheimmunoglobinsuperfamily.MAGisexpressedonmyelinatingoligodenrocytesandSchwanncells,andpreferentiallyrecognizesα2,3linkedsialicacidonOlinkedglycansandgangliosides.MAGexistsastwoisoformswhichdifferinthesequenceandlengthofthecytoplasmictail.Thelargeform(71kDa)andsmallform(67kDa)arisefromalternativesplicedmRNAs.AlthoughMAGmightencounterhaematopoieticcellsandlymphocytesunderpathologicconditions,itwouldnormallybeexpectedtointeractwithneuronalcells.IthasbeenshownthatMAGpromotesaxonalgrowthfromneonatalDRGneuronsandembryonicspinalneurons,butisapotentinhibitorofaxonalregrowthfromadultDRGandpostnatalcerebellarneurons.MAGplaysanimportantroleintheinteractionbetweenaxonsandmyelin.AsolubleformofMAGcontainingtheextracellulardomainisreleasedfrommyelininlargequantitiesandidentifiedinnormalhumantissuesandintissuesfrompatientswithneurologicaldisorders.ThissolubleMAGmightcontributetothelackofCNSneuronregenerationafterinjury.