Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
CD105(26-176a.a.)orEndoglinorGP160isaTypeItransmembraneprotein,whichishighlyexpressedonhumanvascularendothelialcells.ItexistsasanO-andN-glycosylatedhomodimer.Up-regulationofendoglinexpressionhasbeendemonstratedintumorvasculatureandproliferatingcells,suggestingthatitisaproliferation-associatedendothelialcellMarker.CD105bindstoTGFBeta1andBeta3withhighaffinitybutnotTGF-Beta2.
Image:CD105structureandsequence.
References:
1.Targetingamarkerofthetumourneovasculatureusinganovelanti-humanCD105-immunotoxincontainingthenon-toxictype2ribosome-inactivatingproteinnigrinb. CancerLett2007Jul14;
2.Particulardistributionandexpressionpatternofendoglin(CD105)intheliverofpatientswithhepatocellularcarcinoma. BMCCancer2007Jul4;7(1):122
3.DensityofmicrovesselspositiveforCD105(endoglin)isrelatedtoprognosisinmeningiomas. ActaNeuropathol(Berl)2007Aug;114(2):147-56
4.CD105/smoothmuscleactindoubleimmunostainingdiscriminatebetweenimmatureandmaturetumorbloodvessels. RomJMorpholEmbryol2007;48(1):41-5
5.RelationshipbetweenintravascularultrasoundimagingfeaturesofcoronaryplaquesandsolubleCD105levelinpatientswithcoronaryheartdisease. ChinMedJ(Engl)2007Apr5;120(7):595-7
6.[ExpressionsofhTERT,HIF-1alphaandCD105ingliomasandtheirclinicalsignificance] ZhonghuaBingLiXueZaZhi2006Nov;35(11):681-2
