
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllTIE-1(tyrosinekinasewithIgandEGFhomologydomains1)andTIE-2/Tekcompriseareceptortyrosinekinase(RTK)subfamilywithuniquestructuralcharacteristics:twoimmunoglobulin-likedomainsflankingthreeepidermalgrowthfactor(EGF)-likedomainsandfollowedbythreefibronectintypeIII-likerepeatsintheextracellularregionandasplittyrosinekinasedomaininthecytoplasmicregion.ThesereceptorsareexpressedprimarilyonendothelialandhematopoieticProgenitorcellsandplaycriticalrolesinangiogenesis,vasculogenesisandhematopoiesis.HumanTIE-1CDNAencodesa1122aminoacid(aa)residueprecursorproteinwithan18residueputativesignalpeptide,a726residueextracellulardomainanda353residuecytoplasmicdomain.Twoligands,angiopoietin-1(Ang1)andangiopoietin-2(Ang2),whichbindTIE-2withhigh-affinityhavebeenidentified.Ang2hasbeenreportedtoactasanantagoNISTforAng1.MiceengineeredtooverexpressAng2ortolackAng1orTie-1displaysimilarangiogenicdefects.