
Type:Protein
SpeciesReactivity:H;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllAgouti-RelatedProtein(AgRP),theproteinproductoftheAgouti-RelatedTranscript(ART),isaneuropeptidethatregulatesenergymetabolismandthedevelopmentofobesitybyantagonizingα-melanocytestimulatinghormone(α-MSH)onMC-3andMC-4receptors(1-4).AgRPispredominantlyexpressedinthehypothalamusandadrenalmedulla(5).MaturehumanAgRPisa112aapeptide;itsC-terminalportioncontainstenconservedcysteinesthatformfivedisulfidebonds(5,6).HumanAgRPshares82%and72%aasequenceidentitywithmouseandratAgRP,respectively.Itshares32%aasequenceidentitywithAgouti.AsinthecaseofAgouti,theC-terminalcysteine-richregionissufficientforBIOLOGicalactivity(7).AgRPis100timesmorepotentthanAgoutiinantagonizingMC-3andMC-4receptors(8).AgRPalsoinducesinducestheβ-arrestindependentendocytosisofMC-3andMC-4(9).HypothalamicexpressionofAgRPisupregulatedinobesityanddiabetes(5,10),andchronicAgRPadmiNISTrationincreasesfoodintakeandweightgaininrats(11).Genetically-linkedpolymorphismsofAgRPinhumansareassociatedwithsusceptibilitytoanorexianervosa(12,13).Inaddition,AgRPinhibitstheACTH-inducedsynthesisofsteroidhormonesinamechanismthatdoesnotinvolvemelanocortinreceptors(14).
Note:ThisproteinisdesignedforuseasanELISAcontrol.