
Type:Protein
SpeciesReactivity:H;M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllMatrixmetalloproteinase-2(MMP-2)isatypeIVCollagenase,whichisinvolvedinendometrialmenstrualbreakdown,regulationofvascularizationandtheinflammatoryresponse.MMP-2containsanumberofdistinctdomains:aprodomainthatiscleaveduponactivation;acatalyticdomaincontainingthezincbindingsite;afibronectinlikedomainbelievedtohavearoleinsubstratetargeting;andacarboxylterminal(hemopexinlike)domaincontaining2N-linkedglycosylation.TheMMP-2candegradeanextensivearrayofsubstratesincludingtypeIV,V,VIIandXcollagensaswellasgelatintypeI.Inaddition,MMP2interactswithTHBS2,TIMP2,Thrombospondin1,CCL7andTIMP4.MMP-2autocatalyticcleavageintheC-terminalgeneratestheanti-angiogenicpeptide,PEX.ThisprocessseemstobemadepossIBLebybindingintegrinv/beta3.DefectsintheMMP-2arethecauseofTorg-Winchestersyndrome(TWS),akamulticentricosteolysisnodulosisandarthropathy(MONA).