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Neuromics/APP/Protease Nexin II (Human), CF/PR15037CF-10/10 ug

Type:Protein
SpeciesReactivity:H;M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllAmyloidprecursorprotein(APP)isatypeImembraneproteinwithseveralhumanisoformsduetoalternativesplicing.APP-770,-751,and-733containaKunitzproteaseinhibitor(KPI)domain(residue291-342,Accession#NP_000475)andAPP-695doesnot.APPisacellsurfacemoleculewithmanyfunctions.Itcanbeprocessedproteolyticallyintwodifferentpathways.Inonepathway,β-andγ-secretasecleaveattheβsitebetweenresidue670and671andtheγsitebetweenresidue711and714toproduceβ-amyloidpeptide(Aβ40andAβ42),amajorcomponentinplaquesfoundinbrainsofpatientswithAlzheimer"sdisease.Theotherpathwayinvolvesα-secretasethatcleavesresiduesbetween687and688.ItisantiamyloidogenicduetoitsbenigncharacterandthepreventionoftheAβpeptideformation.SolubleAPPcontainingtheKPIdomain,alsoreferredtoasproteasenexinII,isapotentinhibitorofserineproteasesandmayhaveadditionalfunctions.Forexample,itmayregulatethecontactfaceofbloodcoagulationandlimitthrombosisspeciallyinbrainduetoitslocalizationandcoagulationfactorXIinhibitingactivity.