
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllImmunogen:UniProtKB/Swiss-Prot:P05067.3
AmyloidbetaA4protein(APP)functionsasacellsurfacereceptorandtransmembraneprecursorproteinwhichiscleavedbysecretasestoformanumberofpeptides.AnumberofthesepeptidesaresecretedandcanbindtotheacetyltransferasecomplexAPBB1/TIP60tostimulatetranscriptionalactivation,whereasothersformtheproteinbasisoftheamyloidplaquesfoundinthebrainsofpatientswithAlzheimerdisease.APPgenemutationsareimplicatedinautosomaldominantAlzheimerdiseaseandcerebroarterialamyloidosis(cerebralamyloidangiopathy).
APPHumanRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining308aminoacids(18-289a.a)andhavingamolecularmassof34.7kDa(MolecularsizeonSDS-PAGEwillappearhigher). APPisfusedtoa36aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.