
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllApolipoproteinA-1(APOA1)isahumanproteinwithaspecificroleinlipidmetabolismbeingthemainproteincomponentofHDLintheplasma.APOA1promotescholesteroleffluxfromtissuestotheliverforexcretion.FurThermore,APOA1isaco-factorforLCAT,whichisresponsIBLefortheformationofmostplasmacholesterylesters.Inaddition,APOA1activatesspermatozoamotilityaspartoftheSPAPcomplex.TheAPOA1geneisstronglylinkedwithtwootherapolipoproteingenesonchromosome11.DefectsintheAPOA1genearelinkedtoHDLdeficiencyincludingTangierdisease,andwithsystemicnon-neuropathicamyloidosis.HighlevelsofAPOA1arelinkedtothemanifestationofasthmaandatopy.
ApolipoproteinA-IHumanRecombinantproducedinE.coliisasingle,non-glycosylatedpolypeptidechaincontaining244aminoacidsandhavingamolecularmassof28.2kDa. TheAPOA1ispurifiedbyproprietarychromatographictechniques.