
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllMidkine(MK)istheproductofaretinoicacidresponsivegene,MK,andisamemberofafamilyofheparinbindingfactors.Itcontains121aminoacidresiduesincluding10conservedcysteineresidues,allofwhichappeartobedisulphidelinked.
Midkineisexpressedduringembryogenesis,showinganexpressionpatternthatsuggestsfunctionsinneurogenesis,cellmigration,secondaryorganogeneticinduction,andmesoderm-epithelialinteraction.
ThewidespreaddownregulationofMKintheadulthumanisrevertedinanumberofcancers,inwhichpolypeptidesareabletoactasbothtransforminggrowthfactorsandpromotersofangiogenesis.
Midkine(MK),induceschemotaxisofhumanneutrophilsandwasfoundtotriggermobilizationofintracellularcalciumofthesecells.
Midkineinduceshistaminereleasefromratperitonealmastcellswitharapidresponseinadosedependentmanner.
Midkineisalsoapotentstimulatorofcollagenandglycosaminoglycansynthesis.