Neuromics/Noggin/Fc Chimera, Carrier Free/PR15070CF-50/50 ug-免疫在线蚂蚁淘旗下平台

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商品详细Neuromics/Noggin/Fc Chimera, Carrier Free/PR15070CF-50/50 ug

Neuromics/Noggin/Fc Chimera, Carrier Free/PR15070CF-50/50 ug

商品编号： PR15070CF-50

品牌： Neuromics INC

市场价： ¥6300.00

美元价： 3780.00

产地：美国(厂家直采)

公司：

产品分类：细胞代谢

公司分类： cellular_metabolism

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Type:Protein

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

NogginisasecretedhomodimericglycoproteinthatisanantagoNISTofbonemorphogeneticproteins(BMPs).^1,2HumanNogginCDNAencodesa232aminoacid(aa)precursorprotein;cleavageofa19aasignalpeptidegeneratesthe213aamatureproteinwhichcontainsanN-terminalacidicregion,acentralbasicheparin-bindingsegmentandaC-terminalcysteine-knotstructure.²SecretedNogginprobablyremainsclosetothecellsurfaceduetoitsbindingofheparin-containingproteoglycans.³Nogginisveryhighlyconservedamongvertebrates,suchthatmaturehumanNogginshares99%,99%,98%,97%and89%aasequenceidentitywithmouse,rat,bovine,equineandchickNoggin,respectively.NogginbindssomeBMPssuchasBMP-4withhighaffinityandotherssuchasBMP-7withloweraffinity,antagonizingBMPbioactivitiesbyblockingepitopesonBMPsthatareneededforbindingtobothtypeIandtypeIIreceptors.^2,4Duringembryogenesis,NogginantagonizesspecificBMPsatdefinedtimesduringneuraltube,somiteandcardiomyocytegrowthandpatterning.^5-7Duringskeletaldevelopment,Nogginpreventschondrocytehyperplasia,thusallowingproperformationofjoints.⁴Mutationswithinthecysteine-knotregionofhumanNogginarelinkedtomultipletypesofskeletaldysplasiasthatresultinapicaljointfusions.⁸Nogginisexpressedindefinedareasoftheadultcentralnervoussystemandperipheraltissuessuchaslung,skeletalmuscleandskin.¹Duringcultureofhumanembryonicstemcells(hESC)withoutfeederlayersorconditionedmedium,butwithadditionofFGFbasic,additionofNoggintoantagonizeBMPactivityallowshESCtomaintaintheirundifferentiated,pluripotentstate.^9,10

References:

1.Valenzuela,D.M.etal.,1995,J.Neurosci.15:6077-6084.6.Itsykson,P.etal.,2005,Mol.Cell.Neurosci.30:24-36.

2.Groppe,J.etal.,2002,Nature420:636-642.7.Yuasa,S.etal.,2005,Nat.Biotechnol.23:607-611.

3.Paine-Saunders,Setal.,2002,J.Biol.Chem.277:2089-2096.8.Gong,Y.etal.,1999,Nat.Genet.21:302-304.

4.Brunet,L.J.etal.,1998,Science280:1455-1457.9.Xu,R.-H.etal.,2005,Nat.Methods2:185-190.

5.McMahon,J.A.etal.,1998,GenesDev.12:1438-1452.10.Wang,G.etal.,2005,Biochem.Biophys.Res.Commun.330:934-942.

6.Itsykson,P.etal.,2005,Mol.Cell.Neurosci.30:24-36.

7.Yuasa,S.etal.,2005,Nat.Biotechnol.23:607-611.

8.Gong,Y.etal.,1999,Nat.Genet.21:302-304.

9.Xu,R.-H.etal.,2005,Nat.Methods2:185-190.

10.Wang,G.etal.,2005,Biochem.Biophys.Res.Commun.330:934-942.

品牌介绍

NeuromicsNeuromics公司是一家著名的神经科学产品和神经干细胞产品专业供应室，提供一系列高品质新蛋白的抗体、神经干细胞及培养基、神经干细胞扩增及分化试剂盒、干细胞抗体、神经和前体细胞流式分型试剂等。Our unique value is based on providing reagents that are thoroughly tested and characterized. We stand behind our products. If our reagents or cells do not meet expectations, we will fix it. We will either send equal replacement quantities or refund your money. Your satisfaction and feedback are important to our mutual success.产品列表：No.品牌货号名称规格1NeuromicsHMP201GFP Expressing Human Brain Astrocytes500,000 Cells - Frozen2NeuromicsNP4200NeuroProgenitors1,000,000 Cells3NeuromicsHEC02Human Brain Microvascular Endothelial Cells500,000+ Cells frozen4NeuromicsSC00A1-CMHuman Cardiomyocytes500,000 Cells5NeuromicsSC00A8-500Fluorescein Labeled Human Chondrocytes-HCS500,000 Cells6NeuromicsCAF05Human Colorectal Tumor CAFs1,000,000 cells7NeuromicsNS36100Neurosphere Tissue1 Million Cells8NeuromicsPC35120Amygdala1 Amygdala9NeuromicsFBS001FBS - Fetal Bovine Serum100 mL10NeuromicsPC00B7Additional Human alpha Motor Neuron Maintaining Media500 mL11NeuromicsKF17362660 Caspase-1 Assay Kit25-50 Tests12NeuromicsPR27005CNTF20 ug13NeuromicsGT15027Presenilin 1100 ug14NeuromicsEL22000pNF-H Sandwich ELISA Kit1 Kit15NeuromicsPL3000296 Well (High)

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表皮生长因子糖尿病与肥胖骨形态发生蛋白/生长因子疼痛和炎症 ERKs/MAPKs/SAPKs公司 ELISA缓冲液肝细胞生长因子 5羟色胺 BMPs全球发展基金

下丘脑垂体肾上腺轴 PGP 9.5s/UCHL1s系列神经胶质表达所有小分子/肽病毒抗原狐狸基质金属蛋白酶（MMPs）神经退行性疾病内皮细胞标志物糖尿病与肥胖 ILs / CXCLs相关的细胞因子和趋化因子血管内皮生长因子（VEGFs）免疫印迹对照视觉和视网膜瘦素干细胞研究抗体 CRISPR/Cas9型阿片类神经肽细胞周期素基质金属蛋白酶（MMPs）神经丝或NF标记物细胞外基质（ECM）蛋白 iGluRs/AMPAs 低氧诱导因子免疫组化蛋白阵列-1631蛋白新凋亡研究蛋白转基因实验标记物的转染 CD和细胞表面标记卡利克瑞恩斯/克里克斯神经降压素和神经降压素受体等因子重组蛋白 NMDA受体代谢型谷氨酸受体 FLICA体外半胱天冬酶试剂盒内胚层谱系标记转化生长因子阿片受体自闭症/阿斯伯格症 TRPV（香草）；TRPM；TRPA和TRPCs Caspases和组织蛋白酶骨骼肌代谢轴突生长与引导凋亡研究抗体 hMPro人类间充质祖细胞（hMPC）抗体对照 ILs、CCR、CXCs、MIPs和统计轴突生长与引导自闭症/阿斯伯格症大鼠神经球神经原组织次级抗体 CD（分化集群）神经退行性疾病干细胞研究蛋白造血细胞生长因子 γ-氨基丁酸受体癌症脑源性神经营养因子（BDNFs）

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