
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
Basicfibroblastgrowthfactorisamemberofthefibroblastgrowthfactor(FGF)family.FGFfamilymemberspossessbroadmitogenicandcellsurvivalactivities,andareinvolvedinavarietyofBIOLOGicalprocesses,includingembryonicdevelopment,cellgrowth,morphogenesis,tissuerepair,tumorgrowthandinvasion.Thisproteinfunctionsasamodifierofendothelialcellmigrationandproliferation,aswellasanangiogenicfactor.Itactsasamitogenforavarietyofmesoderm-andneuroectoderm-derivedcellsinvitro,thusisthoughttobeinvolvedinorganogenesis.Threealternativelysplicedvariantsencodingdifferentisoformshavebeendescribed.Theheparin-bindinggrowthfactorsareangiogenicagentsinvivoandarepotentmitogensforavarietyofcelltypesinvitro.Therearedifferencesinthetissuedistributionandconcentrationofthese2growthfactors.
Image:FGF2proteinstructureandsequence
References:
1.Trachealcartilageregenerationbyslowreleaseofbasicfibroblastgrowthfactorfromagelatinsponge. JThoracCardiovascSurg2007Jul;134(1):170-5
2.Tissueregenerationobservedinabasicfibroblastgrowthfactor-loadedporousacellularbovinepericardiumpopulatedwithmesenchymalstemcells.JThoracCardiovascSurg2007Jul;134(1):65-73,73.e1-4
3.Theemergingroleofthefibroblastgrowthfactor-23-klothoaxisinrenalregulationofphosphatehomeostasis.JEndocrinol2007Jul;194(1):1-10
4.Prolongedprotectiveeffectofbasicfibroblastgrowthfactor-impregnatednanoparticlesinroyalcollegeofsurgeonsrats. InvestOphthalmolVisSci2007Jul;48(7):3381-7
5.Effectofbasicfibroblastgrowthfactor,trafermin,onentero-relatedfistulae,reportoftwocases. Hepatogastroenterology2007Apr-May;54(75):803-5
6.Segmentboundariesoftheadultratepididymislimitinterstitialsignalingbypotentialparacrinefactorsandsegmentslosedifferentialgeneexpressionafterefferentductligation. AsianJAndrol2007Jul;9(4):565-73