
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllPD-ECGF,alsoknownasTPaseandgliostatin,isproducedbyplacenta,platelets,liver,lung,spleen,lymphnodes,andperipherallymphocytes.Itisoverexpressedbymanytumorsinresponsetochemicalorphysicalstress.PD-ECGFpromotesendothelialcellproliferationandchemotaxisandpromotesangiogenesis.PD-ECGFisakeyenzymeinthepyrimidinenucleosidesalvagepathway.Italsometabolizesandinactivateschemotherapeuticdrugssuchas5-fluorouracilanditsderivatives.ThehumanPD-ECGFCDNAencodesa482aminoacid(aa)polypeptidewitha10aapropeptide.Theproteinislocalizedmostlywithintheproducercells.N-terminaltruncation,resultinginproteinslacking10aaand6aa,hasbeenobservedinPD-ECGFpurifiedformplateletsandplacenta,respectively.Insolution,PD-ECGFexistsasanon-disulfidelinkedhomodimer.ThelatterproteinwaspurifiedfromquiescentastrocytesanddescribedasanastrocyteandastrocytomacellgrowthinhibitorbasedonitsABIlitytoinhibit3H-thymidineincorporation.
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